Inflammatory cell apoptotic process

Across TCGA cell cohorts, RNA activity of the Inflammatory cell apoptotic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MCOLN2, PPP2R5A, and HYLS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Inflammatory cell apoptotic process activity versus MCOLN2 in SKIN (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MCOLN2 →	+1.151	+1.115	.003	.006	3	3
SKIN	PPP2R5A →	+0.802	+1.320	.003	.001	3	3
SOFT_TISSUE	HYLS1 →	+1.656	+0.549	.001	<.001	3	3
BLOOD_Myeloma	TCEANC2 →	+1.125	+1.678	.003	<.001	3	3
LIVER	SYCP2 →	+1.589	+1.837	<.001	<.001	3	3
BLOOD_Myeloma	OTUD7B →	+1.405	+1.678	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006925 vs MCOLN2 — SKIN

Explore this scatter interactively →