Activation-induced cell death of T cells

Across TCGA patient cohorts, RNA activity of the Activation-induced cell death of T cells pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSTPIP1, SASH3, and SERPINB9, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation-induced cell death of T cells activity versus PSTPIP1 in LSCC (Pearson r = 0.59).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PSTPIP1 →	+0.500	+0.085	<.001	<.001	3	8
BRCA	SASH3 →	+0.352	+0.042	<.001	<.001	3	7
LSCC	SERPINB9 →	+0.606	+0.080	<.001	<.001	3	7
GBM	SKAP2 →	+0.561	+0.050	<.001	.003	3	7
GBM	AIF1 →	+0.610	+0.065	.001	<.001	3	7
GBM	FMNL1 →	+0.456	+0.050	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006924 vs PSTPIP1 — LSCC

Explore this scatter interactively →