Activation-induced cell death of T cells

Across TCGA patient cohorts, RNA activity of the Activation-induced cell death of T cells pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RIPK3, PTPN22, and HLA-E, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Activation-induced cell death of T cells activity versus RIPK3 in OV (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RIPK3 →	+0.823	+0.241	<.001	<.001	3	7
LUAD	PTPN22 →	+0.559	+0.149	.007	.007	3	6
PDAC	HLA-E →	+0.297	+0.168	.003	.006	3	5
GBM	CYTH4 →	+0.606	+0.147	<.001	.001	3	4
PDAC	ACER3 →	+0.282	+0.194	.002	.001	3	4
PDAC	PSME1 →	+0.317	+0.160	.002	.003	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006924 vs RIPK3 — OV

Explore this scatter interactively →