Cellular component disassembly involved in execution phase of apoptosis

Across TCGA patient cohorts, RNA activity of the Cellular component disassembly involved in execution phase of apoptosis pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS1, NUF2, and AUNIP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular component disassembly involved in execution phase of apoptosis activity versus GINS1 in LUAD (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GINS1 →	+0.778	+0.156	<.001	.001	3	7
UCEC	NUF2 →	+1.188	+0.289	<.001	<.001	3	7
GBM	AUNIP →	+0.784	+0.348	<.001	<.001	3	7
UCEC	KIF15 →	+1.036	+0.253	.002	.001	3	7
GBM	DEPDC1 →	+0.867	+0.273	<.001	<.001	3	7
UCEC	L2HGDH →	+0.665	+0.358	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006921 vs GINS1 — LUAD

Explore this scatter interactively →