Cellular component disassembly involved in execution phase of apoptosis

Across TCGA cell cohorts, RNA activity of the Cellular component disassembly involved in execution phase of apoptosis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRFIP1, TMBIM1, and SACS, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LRRFIP1 grouped by Cellular component disassembly involved in execution phase of apoptosis-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	LRRFIP1 →	+1.151	+0.626	<.001	.008	3	4
CNS	TMBIM1 →	+0.912	+0.176	.007	.002	3	3
CNS	SACS →	-0.965	-0.214	.004	.004	3	3
SOFT_TISSUE	ANK2 →	-3.112	-1.091	.007	.008	3	3
BONE	POLR1G →	-0.946	-0.271	.002	.001	3	3
BONE	N4BP2L1 →	+1.205	+0.239	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LRRFIP1 by Cellular component disassembly involved in execution phase of apoptosis activity — STOMACH

Explore this box plot interactively →