Cellular component disassembly involved in execution phase of apoptosis

Across TCGA cell cohorts, RNA activity of the Cellular component disassembly involved in execution phase of apoptosis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOP1, PPP2R5A, and EIF1B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular component disassembly involved in execution phase of apoptosis activity versus TOP1 in BLOOD_Lymphoma (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TOP1 →	+0.837	+0.201	.004	.005	3	4
OESOPHAGUS	PPP2R5A →	+0.833	+0.136	.003	.001	3	4
UPPER_AERODIGESTIVE_TRACT	EIF1B →	-0.684	-0.218	.003	.008	3	4
URINARY_TRACT	CAMKMT →	+0.950	+0.302	.008	.002	3	4
URINARY_TRACT	ACYP2 →	+0.839	+0.224	.006	.002	3	4
LUNG_SCLC	JUNB →	+1.441	+0.162	.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006921 vs TOP1 — BLOOD_Lymphoma

Explore this scatter interactively →