"Phagocytosis, engulfment"

Across TCGA patient cohorts, RNA activity of the "Phagocytosis, engulfment" pathway is significantly associated with the RNA expression of multiple genes, with the SARC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MS4A4A, SIGLEC9, and LILRB2, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Phagocytosis, engulfment" activity versus MS4A4A in SARC (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	MS4A4A →	+2.341	+0.079	<.001	<.001	3	34
LAML	SIGLEC9 →	+2.451	+0.076	<.001	<.001	3	34
SARC	LILRB2 →	+1.958	+0.082	<.001	<.001	3	34
BLCA	FCGR2A →	+2.105	+0.064	<.001	<.001	3	34
SARC	FCGR1A →	+1.980	+0.081	<.001	<.001	3	34
SARC	VSIG4 →	+2.633	+0.074	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006911 vs MS4A4A — SARC

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