"Phagocytosis, engulfment"

Across TCGA patient cohorts, RNA activity of the "Phagocytosis, engulfment" pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL21R, CD33, and MS4A6A, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Phagocytosis, engulfment" activity versus IL21R in HNSC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	IL21R →	+0.830	+0.186	<.001	<.001	3	10
UCEC	CD33 →	+0.690	+0.196	<.001	.006	3	10
GBM	MS4A6A →	+1.000	+0.188	<.001	<.001	3	10
GBM	MS4A4A →	+1.003	+0.191	<.001	<.001	3	10
HNSC	SLC15A3 →	+0.846	+0.187	<.001	<.001	3	10
HNSC	BIN2 →	+1.058	+0.257	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006911 vs IL21R — HNSC

Explore this scatter interactively →