"Phagocytosis, engulfment"

Across TCGA cell cohorts, RNA activity of the "Phagocytosis, engulfment" pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DFFB, RING1, and MITF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DFFB grouped by "Phagocytosis, engulfment"-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DFFB →	-0.776	-0.958	<.001	.001	3	4
OESOPHAGUS	RING1 →	-0.888	-1.274	.005	.003	3	4
STOMACH	MITF →	+1.857	+1.078	.001	.001	3	3
STOMACH	ANG →	-2.165	-0.841	<.001	.008	3	3
SOFT_TISSUE	NPC1 →	+0.980	+0.561	.003	.009	3	3
SOFT_TISSUE	CTSS →	+2.094	+0.612	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DFFB by "Phagocytosis, engulfment" activity — STOMACH

Explore this box plot interactively →