"Phagocytosis, engulfment"

Across TCGA cell cohorts, RNA activity of the "Phagocytosis, engulfment" pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF433, BBS9, and CD82, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, "Phagocytosis, engulfment" activity versus ZNF433 in OVARY (Pearson r = 0.53).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ZNF433 →	+1.171	+0.296	<.001	.003	3	7
BONE	BBS9 →	+0.980	+0.187	.002	<.001	3	6
LUNG_NSCLC_LUSC	CD82 →	+4.787	+0.461	.005	<.001	3	6
LIVER	COQ8A →	-1.444	-0.387	.001	.005	3	5
SOFT_TISSUE	TPM4 →	+1.135	+0.295	.007	.004	3	5
LUNG_NSCLC_LUSC	NPC2 →	+1.526	+0.389	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006911 vs ZNF433 — OVARY

Explore this scatter interactively →