Phagocytosis

Across TCGA patient cohorts, RNA activity of the Phagocytosis pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLR2, PIK3AP1, and CLEC4D, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phagocytosis activity versus TLR2 in OV (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TLR2 →	+1.403	+0.240	.001	.005	3	3
OV	PIK3AP1 →	+1.236	+0.214	.001	.006	3	3
COAD	CLEC4D →	+0.671	+0.250	<.001	<.001	3	3
OV	NCF1B →	+0.614	+0.234	.006	.002	3	3
COAD	LNCAROD →	+0.633	+0.242	.006	<.001	3	3
OV	FCGR2B →	+1.256	+0.242	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006909 vs TLR2 — OV

Explore this scatter interactively →