Pinocytosis

Across TCGA patient cohorts, RNA activity of the Pinocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WAS, ANKRD44, and SAMHD1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pinocytosis activity versus WAS in GBM (Pearson r = 0.75).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	WAS →	+0.685	+0.113	<.001	<.001	3	10
LSCC	ANKRD44 →	+0.394	+0.089	<.001	<.001	3	10
HNSC	SAMHD1 →	+0.594	+0.085	<.001	.006	3	9
LSCC	TRIM22 →	+0.531	+0.101	<.001	<.001	3	9
GBM	DEF6 →	+0.647	+0.104	<.001	<.001	3	9
LSCC	DOCK10 →	+0.378	+0.080	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006907 vs WAS — GBM

Explore this scatter interactively →