Pinocytosis

Across TCGA cell cohorts, RNA activity of the Pinocytosis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRR4, AP1AR, and SOS2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pinocytosis activity versus PRR4 in STOMACH (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PRR4 →	+1.192	+1.375	.001	<.001	3	5
LUNG_SCLC	AP1AR →	+0.696	+0.995	<.001	<.001	3	4
BONE	SOS2 →	+0.988	+1.684	.003	.001	3	3
STOMACH	UBE2W →	+1.105	+1.438	.001	<.001	3	3
URINARY_TRACT	NPHP3 →	+1.262	+1.323	.007	.008	2	4
BLOOD_Lymphoma	MAP3K10 →	+0.796	+0.868	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006907 vs PRR4 — STOMACH

Explore this scatter interactively →