Vesicle docking involved in exocytosis

Across TCGA patient cohorts, RNA activity of the Vesicle docking involved in exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF3F, PLEKHA6, and ALCAM, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle docking involved in exocytosis activity versus EIF3F in GBM (Pearson r = -0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EIF3F →	-0.155	-0.056	<.001	<.001	3	5
BRCA	PLEKHA6 →	+0.557	+0.033	.001	.001	3	5
OV	ALCAM →	+1.384	+0.061	.004	.005	3	4
BRCA	EXOC8 →	+0.276	+0.048	<.001	<.001	3	4
BRCA	PGPEP1 →	+0.362	+0.026	<.001	<.001	3	4
LUAD	RAB14 →	+0.229	+0.039	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006904 vs EIF3F — GBM

Explore this scatter interactively →