Vesicle docking involved in exocytosis

Across TCGA patient cohorts, RNA activity of the Vesicle docking involved in exocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PHF23_S64, TSPAN15, and FANCI, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle docking involved in exocytosis activity versus PHF23_S64 in PDAC (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PHF23_S64 →	-0.445	-0.157	<.001	<.001	3	5
PDAC	TSPAN15 →	+0.439	+0.152	.001	.004	3	5
LUAD	FANCI →	-0.491	-0.183	<.001	<.001	3	5
BRCA	MPHOSPH10 →	-0.325	-0.244	<.001	<.001	3	5
BRCA	RNF20 →	-0.243	-0.293	<.001	<.001	3	4
LSCC	SINHCAF →	-0.432	-0.101	<.001	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006904 vs PHF23_S64 — PDAC

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