Vesicle docking involved in exocytosis

Across TCGA cell cohorts, RNA activity of the Vesicle docking involved in exocytosis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SEMA5A, BDP1, and SRGN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle docking involved in exocytosis activity versus SEMA5A in SKIN (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SEMA5A →	+1.933	+0.782	.005	.007	3	6
PANCREAS	BDP1 →	-0.601	-0.913	.001	.003	3	5
BLOOD_Leukemia	SRGN →	+3.328	+0.657	<.001	.002	3	5
OESOPHAGUS	FCMR →	+0.894	+0.509	.001	.003	3	4
BREAST	BTN3A3 →	+1.498	+0.698	.001	.002	3	4
BREAST	TSACC →	-0.780	-0.481	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006904 vs SEMA5A — SKIN

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