Vesicle targeting

Across TCGA patient cohorts, RNA activity of the Vesicle targeting pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF333, PCID2, and RECK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle targeting activity versus ZNF333 in CCRCC (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZNF333 →	-0.336	-0.172	<.001	<.001	3	5
BRCA	PCID2 →	-0.563	-0.309	.001	<.001	3	4
PDAC	RECK →	-0.392	-0.142	.004	.004	3	4
GBM	SLC23A2 →	-0.870	-0.280	.008	.002	2	5
CCRCC	GNG5P3 →	-0.452	-0.125	.004	.004	2	5
BRCA	UTP6 →	-0.406	-0.196	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006903 vs ZNF333 — CCRCC

Explore this scatter interactively →