Vesicle targeting

Across TCGA cell cohorts, RNA activity of the Vesicle targeting pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP6C, HPS4, and XAB2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP6C grouped by Vesicle targeting-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PPP6C →	-0.994	-0.427	.006	.004	2	7
BONE	HPS4 →	-0.355	-0.230	.004	.007	2	5
BONE	XAB2 →	-0.369	-0.262	<.001	<.001	3	4
BREAST	TMED10 →	-0.255	-0.265	<.001	<.001	3	4
LUNG_NSCLC_LUAD	SLC4A5 →	+0.121	+0.249	.003	.008	3	4
SKIN	B9D1 →	-0.170	-0.240	.006	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP6C by Vesicle targeting activity — BLOOD_Myeloma

Explore this box plot interactively →