Vesicle coating

Across TCGA patient cohorts, RNA activity of the Vesicle coating pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL11, FOSL2_S120, and SLC12A2_T217, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle coating activity versus RPL11 in GBM (Pearson r = -0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL11 →	-0.223	-0.037	<.001	.002	3	5
GBM	FOSL2_S120 →	-0.614	-0.036	<.001	.002	3	5
OV	SLC12A2_T217 →	+0.600	+0.033	.003	.006	3	4
OV	SRRM2_S2071 →	-0.509	-0.038	.009	.003	3	4
OV	SRRM2_T1880 →	-1.068	-0.050	.002	.001	3	4
OV	CDC37 →	-0.361	-0.038	.004	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006901 vs RPL11 — GBM

Explore this scatter interactively →