Vesicle coating

Across TCGA cell cohorts, RNA activity of the Vesicle coating pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAPPC13, SOS2, and TRAPPC11, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle coating activity versus TRAPPC13 in BLOOD_Lymphoma (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TRAPPC13 →	+0.946	+0.084	<.001	<.001	3	17
OVARY	SOS2 →	+0.842	+0.076	<.001	<.001	3	16
BLOOD_Myeloma	TRAPPC11 →	+0.892	+0.098	<.001	<.001	3	16
LUNG_SCLC	SPATA7 →	+0.918	+0.098	<.001	<.001	3	16
BLOOD_Leukemia	MFSD8 →	+0.835	+0.078	<.001	<.001	3	16
BLOOD_Lymphoma	ZNF416 →	+1.088	+0.083	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006901 vs TRAPPC13 — BLOOD_Lymphoma

Explore this scatter interactively →