Vesicle budding from membrane

Across TCGA patient cohorts, RNA activity of the Vesicle budding from membrane pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GINS4, POMK, and CREB3L1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Vesicle budding from membrane activity versus GINS4 in GBM (Pearson r = -0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	GINS4 →	-0.781	-0.157	.003	.007	3	6
GBM	POMK →	-0.815	-0.213	.007	.008	3	6
UCEC	CREB3L1 →	+1.147	+0.131	.001	.003	3	6
UCEC	SQLE →	-0.633	-0.136	<.001	.002	3	6
LSCC	ANAPC1 →	-0.561	-0.298	<.001	<.001	3	6
HNSC	XPO5 →	-0.486	-0.109	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006900 vs GINS4 — GBM

Explore this scatter interactively →