Vesicle budding from membrane

Across TCGA cell cohorts, RNA activity of the Vesicle budding from membrane pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MADD, AHRR, and PRKACA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MADD grouped by Vesicle budding from membrane-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MADD →	-0.495	-0.173	.004	.002	3	5
CNS	AHRR →	-1.680	-0.165	.002	.006	3	5
LUNG_NSCLC_LUAD	PRKACA →	-0.608	-0.245	<.001	<.001	3	5
BLOOD_Myeloma	BAD →	-0.846	-0.306	.005	.008	3	4
LUNG_NSCLC_LUAD	POLI →	-0.643	-0.217	.008	.002	3	4
SKIN	TTBK2 →	-0.484	-0.203	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MADD by Vesicle budding from membrane activity — LARGE_INTESTINE

Explore this box plot interactively →