Receptor-mediated endocytosis

Across TCGA cell cohorts, RNA activity of the Receptor-mediated endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CGN, CSNK1A1, and PJA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CGN grouped by Receptor-mediated endocytosis-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CGN →	+2.132	+0.192	.002	.002	3	5
BLOOD_Leukemia	CSNK1A1 →	-0.857	-0.235	.004	.002	3	4
BLOOD_Leukemia	PJA2 →	-0.629	-0.153	.006	<.001	3	4
LUNG_NSCLC_LUAD	CD70 →	-2.158	-0.136	.003	.009	2	5
LUNG_NSCLC_LUAD	HIGD2A →	-0.744	-0.175	.001	.002	3	4
LIVER	PLXNC1 →	+2.221	+0.284	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CGN by Receptor-mediated endocytosis activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →