Receptor-mediated endocytosis

Across TCGA cell cohorts, RNA activity of the Receptor-mediated endocytosis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA1958, FAM117B, and TWNK, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor-mediated endocytosis activity versus KIAA1958 in LUNG_NSCLC_LUSC (Pearson r = -0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KIAA1958 →	-1.380	-0.280	.003	.009	3	10
STOMACH	FAM117B →	-1.463	-0.394	<.001	.001	3	9
CNS	TWNK →	-0.714	-0.181	.001	.005	3	9
CNS	VASN →	+3.508	+0.289	<.001	.002	3	8
BLOOD_Lymphoma	TERT →	-1.804	-0.198	.004	.002	3	8
LARGE_INTESTINE	SMPD1 →	+1.936	+0.233	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006898 vs KIAA1958 — LUNG_NSCLC_LUSC

Explore this scatter interactively →