Receptor-mediated endocytosis

Across TCGA cell cohorts, RNA activity of the Receptor-mediated endocytosis pathway is significantly associated with the protein abundance of multiple proteins, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AP2M1, AP2S1, and AP2A1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Receptor-mediated endocytosis activity versus AP2M1 in BONE (Pearson r = 0.69).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	AP2M1 →	+1.325	+0.350	<.001	<.001	3	16
LIVER	AP2S1 →	+1.354	+0.262	.004	<.001	3	15
BONE	AP2A1 →	+1.018	+0.249	<.001	<.001	3	14
PANCREAS	CCT7 →	-1.255	-0.277	.002	.002	3	14
BREAST	PUF60 →	-0.721	-0.261	<.001	<.001	3	14
SOFT_TISSUE	NASP →	-1.774	-0.256	.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006898 vs AP2M1 — BONE

Explore this scatter interactively →