Golgi to vacuole transport

Across TCGA patient cohorts, RNA activity of the Golgi to vacuole transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DEPDC1, CSE1L, and SEPTIN14P12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi to vacuole transport activity versus DEPDC1 in UCEC (Pearson r = -0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DEPDC1 →	-0.784	-0.257	.006	<.001	3	6
CCRCC	CSE1L →	-0.278	-0.162	<.001	<.001	3	6
PDAC	SEPTIN14P12 →	-0.410	-0.158	.006	.004	3	5
BRCA	TPX2 →	-1.030	-0.191	<.001	<.001	3	5
UCEC	CCNB1 →	-1.077	-0.193	<.001	.008	3	5
UCEC	HMGA1 →	-0.789	-0.236	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006896 vs DEPDC1 — UCEC

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