Golgi to endosome transport

Across TCGA patient cohorts, RNA activity of the Golgi to endosome transport pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADD3_S650, MAP1B_S2271, and ARFGEF3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi to endosome transport activity versus ADD3_S650 in BRCA (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ADD3_S650 →	+0.806	+0.060	<.001	<.001	3	6
LUAD	MAP1B_S2271 →	+0.706	+0.030	.001	.003	3	5
BRCA	ARFGEF3 →	+0.546	+0.065	.001	<.001	3	5
BRCA	PRKG1 →	+0.547	+0.051	<.001	<.001	3	5
HNSC	SVIL_S547 →	+0.668	+0.042	.003	.006	3	5
BRCA	WDHD1 →	-0.312	-0.046	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006895 vs ADD3_S650 — BRCA

Explore this scatter interactively →