Golgi to endosome transport

Across TCGA cell cohorts, RNA activity of the Golgi to endosome transport pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UCP2, ZNF564, and TUSC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UCP2 grouped by Golgi to endosome transport-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	UCP2 →	-1.901	-0.851	.006	.001	3	4
CNS	ZNF564 →	+0.294	+0.861	.003	.006	3	3
BREAST	TUSC3 →	+2.003	+0.933	.003	<.001	3	3
BREAST	RFX5 →	-0.834	-0.766	<.001	<.001	3	3
LUNG_SCLC	BAK1 →	+0.984	+1.483	.004	<.001	3	3
SOFT_TISSUE	SULF2 →	+3.531	+1.672	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UCP2 by Golgi to endosome transport activity — OVARY

Explore this box plot interactively →