Golgi to endosome transport

Across TCGA cell cohorts, RNA activity of the Golgi to endosome transport pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX12, ACSF2, and MEGF8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Golgi to endosome transport activity versus SNX12 in STOMACH (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SNX12 →	+0.734	+1.233	<.001	<.001	3	4
STOMACH	ACSF2 →	+2.024	+1.385	.007	<.001	3	4
BREAST	MEGF8 →	+1.095	+0.889	<.001	.002	3	4
BREAST	TNFAIP1 →	+0.783	+0.609	.001	.004	3	4
OVARY	TMEM70 →	-0.647	-0.788	<.001	.002	3	4
BLOOD_Lymphoma	POR →	+0.845	+0.999	.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006895 vs SNX12 — STOMACH

Explore this scatter interactively →