Regulation of pH

Across TCGA patient cohorts, RNA activity of the Regulation of pH pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANKRD44, SAMHD1, and SRRM2_S2694, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pH activity versus ANKRD44 in COAD (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ANKRD44 →	+0.307	+0.016	<.001	<.001	3	7
GBM	SAMHD1 →	+0.333	+0.035	.002	.001	3	6
BRCA	SRRM2_S2694 →	-0.357	-0.013	.002	.003	3	6
LSCC	CD40 →	+0.500	+0.034	.001	<.001	3	6
GBM	PLCB2 →	+0.507	+0.042	<.001	<.001	3	6
COAD	TBC1D1 →	+0.348	+0.013	.005	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006885 vs ANKRD44 — COAD

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