Regulation of pH

Across TCGA cell cohorts, RNA activity of the Regulation of pH pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTF1A, CHMP4C, and GIP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTF1A grouped by Regulation of pH-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	PTF1A →	-0.135	-0.078	.004	.004	3	5
LARGE_INTESTINE	CHMP4C →	-0.167	-0.042	.004	.003	3	5
URINARY_TRACT	GIP →	-0.237	-0.131	.005	.008	3	4
SKIN	DHX33 →	-0.138	-0.067	.006	.002	3	4
LARGE_INTESTINE	ARHGAP27P1-BPTFP1-KPNA2P3 →	-0.475	-0.086	<.001	<.001	3	4
LUNG_NSCLC_LUSC	PLPBP →	+0.256	+0.071	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTF1A by Regulation of pH activity — BONE

Explore this box plot interactively →