Regulation of pH

Across TCGA cell cohorts, RNA activity of the Regulation of pH pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC20, ATP6AP1, and GNPTG, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pH activity versus CDC20 in STOMACH (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CDC20 →	-1.088	-0.063	.008	.001	3	11
SOFT_TISSUE	ATP6AP1 →	+0.829	+0.076	<.001	<.001	3	9
SKIN	GNPTG →	+0.785	+0.052	<.001	<.001	3	9
BREAST	TMEM175 →	+1.014	+0.075	.005	.001	3	9
SOFT_TISSUE	NCAPH →	-0.890	-0.081	<.001	<.001	3	9
BLOOD_Myeloma	GBA →	+1.425	+0.062	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006885 vs CDC20 — STOMACH

Explore this scatter interactively →