Regulation of pH

Across TCGA cell cohorts, RNA activity of the Regulation of pH pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL10A, EEF1B2, and RPS3A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of pH activity versus RPL10A in STOMACH (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RPL10A →	-1.097	-0.257	.003	.005	3	8
OESOPHAGUS	EEF1B2 →	-1.088	-0.304	.001	.001	3	7
LARGE_INTESTINE	RPS3A →	-0.787	-0.229	<.001	<.001	3	7
OVARY	RPS10 →	-0.696	-0.203	.002	.001	3	6
PANCREAS	ATP6V0C →	+0.981	+0.314	<.001	<.001	3	6
LARGE_INTESTINE	ATP6AP1 →	+1.148	+0.250	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006885 vs RPL10A — STOMACH

Explore this scatter interactively →