Cell volume homeostasis

Across TCGA patient cohorts, RNA activity of the Cell volume homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LMO7, COIL, and FIS1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell volume homeostasis activity versus LMO7 in LSCC (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	LMO7 →	+0.295	+0.048	.001	<.001	3	6
LSCC	COIL →	-0.332	-0.038	.001	.001	3	5
COAD	FIS1 →	+0.407	+0.027	.004	<.001	3	5
GBM	VPS53 →	+0.209	+0.064	<.001	<.001	3	5
PDAC	GSTK1 →	+0.376	+0.037	.001	<.001	3	5
GBM	GPD1 →	+1.142	+0.050	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006884 vs LMO7 — LSCC

Explore this scatter interactively →