Cell volume homeostasis

Across TCGA patient cohorts, RNA activity of the Cell volume homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC25A4, GAS6-DT, and TNFSF11, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell volume homeostasis activity versus SLC25A4 in GBM (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC25A4 →	+0.431	+0.186	<.001	.001	3	4
HNSC	GAS6-DT →	-0.643	-0.642	<.001	<.001	3	3
OV	TNFSF11 →	-0.428	-0.386	.009	.008	3	3
OV	GOLGA2P10 →	+0.639	+0.509	.002	.002	2	4
GBM	CCN6 →	+0.131	+0.144	.009	.003	3	3
CCRCC	AMELX →	+0.453	+0.561	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006884 vs SLC25A4 — GBM

Explore this scatter interactively →