Cell volume homeostasis

Across TCGA patient cohorts, RNA activity of the Cell volume homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NOS3, ATP1A1, and TRIP10_S351, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell volume homeostasis activity versus NOS3 in OV (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NOS3 →	+0.916	+0.495	<.001	.001	3	3
PDAC	ATP1A1 →	+0.534	+0.646	<.001	<.001	3	3
GBM	TRIP10_S351 →	-0.709	-0.237	<.001	<.001	3	3
OV	SRRM1_T574 →	-0.921	-0.389	<.001	<.001	3	3
LSCC	DDX10_S807 →	-0.962	-0.362	<.001	<.001	3	3
GBM	WDR26_S121 →	-0.467	-0.239	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006884 vs NOS3 — OV

Explore this scatter interactively →