Cell volume homeostasis

Across TCGA cell cohorts, RNA activity of the Cell volume homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DHRS12, BCAS4, and CDC16, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DHRS12 grouped by Cell volume homeostasis-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DHRS12 →	-0.592	-0.909	.009	.001	3	6
SOFT_TISSUE	BCAS4 →	-1.909	-1.455	.001	<.001	3	4
SOFT_TISSUE	CDC16 →	-0.604	-1.256	.009	.002	3	4
SOFT_TISSUE	CCDC71 →	-0.691	-1.897	<.001	<.001	3	4
SOFT_TISSUE	ALG11 →	-0.730	-1.747	.005	<.001	3	4
SOFT_TISSUE	CATSPERG →	-1.243	-1.540	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DHRS12 by Cell volume homeostasis activity — SKIN

Explore this box plot interactively →