Intracellular sodium ion homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular sodium ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC12A2, HES1, and GTF2IP7, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular sodium ion homeostasis activity versus SLC12A2 in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC12A2 →	+1.259	+0.717	<.001	<.001	3	5
BRCA	HES1 →	+0.822	+0.754	<.001	<.001	3	5
LSCC	GTF2IP7 →	+0.667	+0.213	.003	.001	3	5
BRCA	ELAPOR1 →	+1.384	+0.615	<.001	<.001	3	5
LSCC	ATP2C2 →	+0.760	+0.212	<.001	<.001	3	5
GBM	UPP2 →	+0.592	+0.256	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006883 vs SLC12A2 — BRCA

Explore this scatter interactively →