Intracellular sodium ion homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular sodium ion homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATP1B1, ATP1A1, and MFSD6_T10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular sodium ion homeostasis activity versus ATP1B1 in GBM (Pearson r = 0.70).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ATP1B1 →	+0.778	+0.293	<.001	<.001	3	7
UCEC	ATP1A1 →	+0.713	+0.725	<.001	<.001	2	7
BRCA	MFSD6_T10 →	+0.905	+0.801	<.001	<.001	3	6
UCEC	SLC12A2 →	+0.644	+0.539	<.001	<.001	3	5
BRCA	SLC12A2_S242 →	+1.552	+0.982	.006	.003	1	7
UCEC	SLC12A2_S77 →	+0.847	+0.566	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006883 vs ATP1B1 — GBM

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