Intracellular sodium ion homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular sodium ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2U1, CYP4F2, and OLFM1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP2U1 grouped by Intracellular sodium ion homeostasis-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CYP2U1 →	-0.727	-0.898	.002	.002	3	4
LARGE_INTESTINE	CYP4F2 →	-0.934	-0.759	.005	.006	3	4
SKIN	OLFM1 →	-2.534	-0.762	.001	.004	3	4
UPPER_AERODIGESTIVE_TRACT	CARS2 →	-1.148	-1.636	.008	<.001	3	3
PANCREAS	FSTL1 →	-2.655	-0.817	.002	.007	3	3
OESOPHAGUS	MRPL34 →	-0.782	-0.923	.009	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP2U1 by Intracellular sodium ion homeostasis activity — PANCREAS

Explore this box plot interactively →