Intracellular zinc ion homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular zinc ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MT2A, MT1G, and MT1E, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular zinc ion homeostasis activity versus MT2A in GBM (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MT2A →	+0.974	+0.148	<.001	<.001	3	7
UCEC	MT1G →	+1.556	+0.245	.001	<.001	3	7
UCEC	MT1E →	+2.178	+0.321	<.001	<.001	3	5
CCRCC	SLC39A14 →	+0.824	+0.274	<.001	.004	3	4
GBM	MT1X →	+1.252	+0.224	<.001	<.001	3	4
UCEC	DPPA2P4 →	+0.420	+0.188	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006882 vs MT2A — GBM

Explore this scatter interactively →