Intracellular zinc ion homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular zinc ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALKBH6, TTC23, and BYSL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ALKBH6 grouped by Intracellular zinc ion homeostasis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ALKBH6 →	+0.402	+0.906	.007	.004	3	4
BLOOD_Lymphoma	TTC23 →	+1.627	+1.812	.002	<.001	3	3
BLOOD_Leukemia	BYSL →	-0.585	-1.120	.004	<.001	3	3
BLOOD_Leukemia	SHISA5 →	-0.445	-1.074	.004	.001	3	3
BLOOD_Myeloma	RNF14 →	+0.852	+1.650	.006	.002	3	3
LUNG_NSCLC_LUAD	DHRS12 →	-0.489	-0.641	.007	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ALKBH6 by Intracellular zinc ion homeostasis activity — CNS

Explore this box plot interactively →