Intracellular zinc ion homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular zinc ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TIMP1, MT1F, and SUSD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular zinc ion homeostasis activity versus TIMP1 in BLOOD_Lymphoma (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TIMP1 →	+5.175	+0.396	<.001	.007	3	4
BLOOD_Lymphoma	MT1F →	-2.539	-0.553	.007	.001	3	4
OESOPHAGUS	SUSD1 →	-1.361	-0.592	<.001	.001	3	3
OESOPHAGUS	LCA5 →	-1.135	-0.935	.003	.004	3	3
OESOPHAGUS	VSTM5 →	-0.755	-0.517	.005	.005	3	3
OESOPHAGUS	ICA1 →	-2.357	-0.532	.005	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006882 vs TIMP1 — BLOOD_Lymphoma

Explore this scatter interactively →