Intracellular iron ion homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular iron ion homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CLNS1A, DDX27, and RRP7A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular iron ion homeostasis activity versus CLNS1A in LSCC (Pearson r = -0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CLNS1A →	-0.279	-0.031	<.001	<.001	3	7
LSCC	DDX27 →	-0.274	-0.029	<.001	<.001	3	7
LSCC	RRP7A →	-0.489	-0.046	<.001	<.001	3	6
LSCC	SMNDC1 →	-0.301	-0.040	.001	<.001	3	6
LSCC	TRMT6 →	-0.560	-0.049	<.001	<.001	3	6
LSCC	CAV1_S37 →	+0.724	+0.039	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006879 vs CLNS1A — LSCC

Explore this scatter interactively →