Intracellular iron ion homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular iron ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAMD10, PORCN, and ANKS3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SAMD10 grouped by Intracellular iron ion homeostasis-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SAMD10 →	+1.422	+0.218	.001	<.001	3	5
LARGE_INTESTINE	PORCN →	-1.302	-0.178	<.001	<.001	2	6
SKIN	ANKS3 →	-0.528	-0.214	.002	.005	3	5
PANCREAS	NBPF3 →	-1.185	-0.193	.001	.005	3	4
URINARY_TRACT	CIAO1 →	-0.650	-0.387	.004	.002	3	4
UPPER_AERODIGESTIVE_TRACT	DYRK1B →	-1.192	-0.111	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SAMD10 by Intracellular iron ion homeostasis activity — OESOPHAGUS

Explore this box plot interactively →