Intracellular iron ion homeostasis

Across TCGA cell cohorts, RNA activity of the Intracellular iron ion homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OLFM2, FCHO2, and PRTG, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular iron ion homeostasis activity versus OLFM2 in BLOOD_Lymphoma (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OLFM2 →	+0.226	+0.147	.002	<.001	3	4
BLOOD_Leukemia	FCHO2 →	+1.347	+0.130	<.001	<.001	3	4
BLOOD_Leukemia	PRTG →	+0.413	+0.119	.008	.004	3	4
LUNG_NSCLC_LUAD	RPL11 →	-0.602	-0.147	.005	.003	3	4
LUNG_SCLC	PRMT5 →	-0.757	-0.172	.001	<.001	3	4
BLOOD_Lymphoma	STEAP2 →	+0.095	+0.151	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006879 vs OLFM2 — BLOOD_Lymphoma

Explore this scatter interactively →