Glutamine transport

Across TCGA patient cohorts, RNA activity of the Glutamine transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADAMTS9-AS2, C7, and CYYR1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamine transport activity versus ADAMTS9-AS2 in LSCC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADAMTS9-AS2 →	-0.481	-0.810	<.001	<.001	3	7
OV	C7 →	-2.418	-0.231	<.001	<.001	3	6
BRCA	CYYR1 →	-0.704	-0.649	<.001	.001	3	6
LSCC	ZBTB20 →	-0.565	-0.817	<.001	<.001	3	6
BRCA	COL14A1 →	-1.290	-0.880	.001	<.001	3	6
PDAC	ZNF728 →	-0.647	-0.922	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006868 vs ADAMTS9-AS2 — LSCC

Explore this scatter interactively →