Glutamine transport

Across TCGA cell cohorts, RNA activity of the Glutamine transport pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CHRAC1, N4BP3, and THEM4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CHRAC1 grouped by Glutamine transport-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CHRAC1 →	+0.956	+1.582	.007	<.001	3	4
BLOOD_Myeloma	N4BP3 →	-1.001	-1.394	<.001	<.001	3	4
BLOOD_Leukemia	THEM4 →	+2.523	+1.155	.001	.001	3	4
BLOOD_Lymphoma	C6orf120 →	+0.950	+2.015	<.001	<.001	3	4
SOFT_TISSUE	SNTA1 →	-1.117	-1.719	<.001	<.001	3	3
LARGE_INTESTINE	C16orf70 →	-0.610	-0.926	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHRAC1 by Glutamine transport activity — LIVER

Explore this box plot interactively →