Glutamine transport

Across TCGA cell cohorts, RNA activity of the Glutamine transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC1A5, TPM2, and ITGB3BP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamine transport activity versus SLC1A5 in LUNG_SCLC (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLC1A5 →	+1.403	+0.908	.004	.008	3	7
SKIN	TPM2 →	-3.195	-0.409	.004	.006	3	5
CNS	ITGB3BP →	+0.827	+0.229	.003	.003	3	4
CNS	GZMM →	+0.211	+0.189	.002	.002	3	4
BREAST	TTC13 →	+0.887	+0.240	.001	.007	3	4
BREAST	GPRC5B →	-1.367	-0.206	.004	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0006868 vs SLC1A5 — LUNG_SCLC

Explore this scatter interactively →