Amino acid transport

Across TCGA cell cohorts, RNA activity of the Amino acid transport pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HRH3, PITPNM2, and DNAJB12, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HRH3 grouped by Amino acid transport-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	HRH3 →	-0.495	-1.880	.006	<.001	2	6
BLOOD_Leukemia	PITPNM2 →	-0.132	-0.931	.001	.002	3	5
BONE	DNAJB12 →	-0.188	-1.815	.002	<.001	3	5
SOFT_TISSUE	ARHGAP29 →	-0.240	-1.300	.002	.004	3	5
OVARY	SLC16A8 →	-0.182	-0.960	.009	.003	3	5
LUNG_NSCLC_LUAD	ADCY4 →	-0.166	-0.884	.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HRH3 by Amino acid transport activity — BONE

Explore this box plot interactively →